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This post was adapted from episode 33 of the Nourished & Free™ podcast: "Dietitian Review of GLP-1 Drugs for Weight Loss and what NO ONE is telling you! " Listen to the full episode. Special thanks to Dr. Idz for discussing this topic with me! If you haven’t heard about Ozempic, Wegovy, or Mounjaro by now - you probably live under a rock. These drugs are in high demand as people are snatching them up as the latest weight loss solution. But do they deliver on helping people lose weight? What about side effects, long-term effects, and cost? I’m breaking it all down (and more) in this dietitian review of GLP-1 drugs for weight loss. What are GLP-1 Drugs? GLP-1 drugs were initially designed for diabetes management but have since grown in popularity for weight loss. GLP-1 (glucagon-like peptide 1) is a hormone naturally produced in the intestines. Increase in insulin secretion by stimulating the release of insulin from pancreatic beta cells, which helps to lower blood sugar levels.

Inhibits the release of glucagon, which is a hormone that raises blood sugar. This further helps to lower blood sugar levels. GLP-1 agonists also act on the brain’s appetite centers, helping to reduce hunger and promote fullness. Let’s walk through each of these drugs real quick and talk about some basic info, then dig into what the research says about using GLP-1 drugs for weight loss. Ozempic is one of the GLP-1 drugs that you hear of the most these days. Ozempic is used for diabetes due to the positive effects it has on blood sugar management, however now many are doing Ozempic shots for weight loss. With the emergence of Wegovy, many are now using that instead of Ozempic. But what is Wegovy, and what is the difference between Ozempic and Wegovy? Ozempic is the FDA approved semaglutide for diabetes. After semaglutide became FDA approved for weight loss in obese individuals, it started being sold as Wegovy.

They are the same drug, just separate names for different FDA-approved intended purposes. But do semaglutides really work? Will Ozempic really work for weight loss? To see more about the research on whether semaglutides work for weight loss, jump here. Or, keep reading to learn the difference between the various GLP-1 drugs, the side effects, and the costs involved. Wegovy and Ozempic are both semaglutides. Mounjaro is a tirzepatide. Let’s dive into the differences between semaglutide vs tirzepatide. Semaglutides (Wegovy and Ozempic) act only by activating glucagon-like peptide 1 (GLP-1) receptors, whereas tirzepatide (Mounjaro) activates both the GLP-1 receptors and glucose-dependent insulinotropic polypeptide (GIP). GIP stimulates insulin to release after a meal, which insulin is of course key in regulating blood glucose. Therefore, the difference is Mounjaro (tizepatide) activates two agents working to secrete insulin while Ozempic or Wegovy (semaglutide) only activate one agent to secrete insulin. Ozempic, Wegovy, and Mounjaro are all injectibles that are inserted subcutaneously (under the skin).

Can be increased to up to 2.0 (moving along in 4 week increments) depending on how the patient is responding. Wegovy 0.5 once a week for a month. Wegovy 2.5 in the final month and is sustained as a maintenance dose. Mounjaro shots for weight loss follow a similar titration schedule as Ozempic and Wegovy do. With insurance, Ozempic’s price is next to nothing. Without insurance, the cost of 1 monthly dose Ozempic pen is a shocking $935. But it doesn’t stop there. The out-of-pocket rates for 1 monthly dosage of Wegovy might bring you to tears: Wegovy’s cost is a cool $1,349. There are some ways to get bring down the out-of-pocket cost with Wegovy coupons and Ozempic coupons from sites like GoodRx. Mounjaro is no exception. Does insurance cover Ozempic? Does insurance cover Wegovy and other GLP-1 drugs? Depends on your insurance plan. Additionally, the only FDA approved GLP-1 drugs for MedicGLP Weight Management loss are Wegovy and MedicGLP Capsules Saxenda. Ozempic, Mounjaro, Victoza, and Trulicity are technically for diabetes. For a refresher on the difference between all these drugs with their crazy names, go here. It’s important to consider the potential side effects of any new drug that you’re considering. Let’s look at the side effect of semaglutide. One study showed that 84% of people taking semaglutide experienced gastrointestinal issues such as diarrhea. Part of its interaction is to reduce glucose absorption from the gut therefore there is more sugar and water in the intestines, potentially causing the diarrhea. What about Ozempic and throwing up? More than 10% of people may experience nausea and hypoglycemia as a side effect of Ozempic or as a Wegovy side effect.

Science continues to prove that the old adage "you are what you eat" is profoundly true. This is because you have trillions of microorganisms living in your gut, which are directly responsible for nearly every aspect of your health. These microbes make up what’s called your "gut microbiota." They are especially influential in determining your likelihood of gaining excessive weight, becoming obese, and developing obesity-related diseases like diabetes, heart disease, and premature death. The gut microbiome (the expressed genes of your gut microbiota) plays a major role in your metabolism through energy production, storage, and expenditure. So, it’s no surprise that science has found a strong connection between gut microbiome imbalance and metabolic syndrome. Yikes! If you have the wrong mix of microbes, it could be making it tough for you to get your health on track! Did you know: Scientists can actually look at your gut microbiome composition and tell with 90% accuracy if you are obese or lean. That’s pretty impressive, isn’t it?