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The Complete Guide to Polynucleotides

Polynucleotides have as one of the most exciting developments in aesthetic medicine and skin rejuvenation. This comprehensive guide covers everything you need to know about this .

What are Polynucleotides?

Polynucleotides are long chains of nucleotides, which are the building blocks of DNA and RNA. These molecules are derived from salmon DNA, which has been found to be highly biocompatible with human tissue.

The treatment works at a cellular level to tissue repair, production, and improve skin quality.

How do polynucleotides work?

Polynucleotides through mechanisms:

regeneration: They activity, encouraging the of new and elastin fibres.

Hydration: The treatment improves the skin's to retain moisture, resulting in better hydration levels.

Tissue repair: the repair of tissue and accelerate healing processes.

Key benefits of polynucleotides

Polynucleotides treatments offer numerous advantages for skin health and appearance:

skin and tone

Reduction in fine lines and wrinkles

skin and elasticity

Brighter, more radiant complexion

in pigmentation and dark circles (particularly around the eyes)

Minimised appearance of scars and stretch marks

Overall skin rejuvenation

Which areas can be treated with polynucleotides?

At Karwal Aesthetics, we offer Plinest for areas of the face and body:

Face: Mid-face and lower face

Eyes: area, crow's feet, upper eyelids

Neck and décolletage: For addressing crepey skin and lines

Hands: To improve skin quality and reduce visible signs of ageing

The Treatment Process

Before treatment, you'll have a consultation with a who will assess your skin concerns, medical history, and suitability for the procedure. They'll recommend the most appropriate and treatment plan.

At Karwal Aesthetics, we use polynucleotides, however, we have other treatment that could be based on your and concerns during a consultation with Dr Arun.

The treatment takes minutes and involves:

Cleansing and the area

topical anaesthetic if needed (though many patients find the treatment comfortable it)

Injecting the polynucleotide solution using fine or cannulas

points are used to ensure even distribution

Gentle massage to the evenly

After your polynucleotides treatment, you should:

Avoid or rubbing the area for 6-8 hours

Stay out of direct sunlight and avoid heat (saunas, steam rooms) for 48 hours

Avoid strenuous for 24 hours

Keep the area clean and moisturised

Avoid makeup for hours if possible

How many polynucleotide sessions are needed?

The number of treatments required varies on concerns and goals:

Initial course: Typically 2-4 spaced 2-4 weeks apart

Maintenance: Follow-up treatments every 6 months to results

Severe concerns: May more intensive protocols

When will I see results from polynucleotides?

Results from polynucleotide develop gradually:

Immediate: Some hydration and subtle glow may be straight away

2-4 weeks: Noticeable improvements in skin texture and tone

4-8 weeks: More as collagen increases

3-6 months: Optimal become apparent

Results typically last 6-12 months, depending on individual factors such as age, lifestyle, and skin condition.

Potential side effects

Polynucleotide treatments are generally well-tolerated, but some temporary side effects may occur:

Mild at injection sites

Slight (more common in sensitive areas)

or tenderness

Small bumps at points

These typically resolve within hours. side effects are rare when by practitioners.

Who is suitable for polynucleotides treatment?

Polynucleotides are for most adults to their skin . Ideal candidates include those who:

Have early to moderate signs of ageing

Want rejuvenation without fillers

Have sun-damaged or dehydrated skin

Are looking for treatments

Have expectations about results

Who should avoid polynucleotides?

Polynucleotides may not be if you:

Are or breastfeeding

Have active infections or inflammation in the area

Have a known allergy to polynucleotides or salmon products

Have autoimmune conditions

Are taking blood-thinning (discuss with your practitioner)

Have a of keloid scarring

How Does Plinest Compare to Other Treatments?

Both Plinest Polynucleotides and Profhilo are bio-remodelling treatments that stimulate skin rejuvenation, but they differ in their composition and approach:

Active ingredients: Profhilo contains highly concentrated hyaluronic acid (HA), whilst Polynucleotides uses polynucleotides from salmon DNA.

of action: Profhilo works through with HA to and production in four types of . Polynucleotides works by directly stimulating and has additional anti-inflammatory and .

Injection technique: Profhilo typically uses the BAP (Bio Points) technique with 5 injection points per side of the face, whilst injection points distributed across the area.

Spread: Profhilo; similar website,'s unique formulation allows it to spread more easily under the skin after injection, whilst more to the injection sites.

vs. regeneration: Profhilo primarily focuses on intense and bio-remodelling, whilst Polynucleotides emphasises cellular regeneration, tissue repair, and effects.

Treatment areas: Both can be used on similar areas, though Profhilo is particularly noted for its lifting and on the face and neck, whilst offers targeted formulations like Plinest Eye for concerns.

Results: Both natural-looking improvements. However, Profhilo is the at Karwal Aesthetics between the two. delivers a natural glow, plumpness, and hydration to the skin.

Both Polynucleotides and Sunekos are bio-revitalisation treatments, but they differ in their and mechanisms of action. Sunekos contains a patented formula of hyaluronic acid combined with a blend of amino acids, whilst Polynucleotides uses from salmon DNA.

Key differences include:

Active ingredients: Sunekos relies on hyaluronic acid and amino acids to stimulate the matrix, whereas uses polynucleotides for and tissue repair.

Mechanism: Sunekos works by providing the building blocks for and elastin synthesis, whilst activity and has additional anti-inflammatory and properties.

Treatment areas: Both can be used on similar areas, though Plinest Eye is specifically for the periorbital region, whilst has different ( 200 and Sunekos 1200) for varying levels of skin laxity.

Results: Both provide improvements. However, is the preferred at Karwal Aesthetics, delivering more dramatic results and better improvement in hyperpigmentation, fine lines, and skin texture—especially crepey skin.

Conclusion

represent an innovative approach to skin rejuvenation, results through rather than synthetic volume . With minimal downtime, broad applications, and mechanisms of action, they've become a popular choice for those seeking to improve their skin quality and signs of ageing.

As with any treatment, depends on choosing a qualified practitioner, having expectations, and following a proper plan. If you're considering Plinest, a consultation with a registered professional to discuss whether this is right for your specific and goals.

Where we offer Plinest treatments

We offer Plinest treatments at our clinic in London Mayfair. Our practice is located in the heart of Mayfair, one of London's most areas, making it easily for across the .

Address: 15 Dover Street, London, W1S 4LP

Our clinic provides a and discreet where you can receive your Polynucleotides treatments from Dr Arun, an aesthetic practitioner. The clinic is equipped with modern and adheres to the highest standards of safety and hygiene.

By Underground: Green Park (Jubilee, Piccadilly, and lines) is just a short walk away

By Bus: Multiple bus routes serve the area

By Car: Limited paid street parking available; several car parks nearby

To book your or treatment, .

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Business Enquiries

Mayfair, London
2nd Floor, 15 Dover Street, W1S 4LP

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0% finance is available on all treatments from £500. Find out more by visiting our Plan page.

Please note: our clinic is on the second floor with stair access only.

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